极速11选5

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戚世乾研究员团队联合清华闫创业教授团队在PNAS发表研究论文,揭示C9orf72复合体结构和全新功能 2020.04.21

JINRI,WOYUANSHENGWUZHILIAOGUOJIAZHONGDIANSHIYANSHIQISHIQIANYANJIUYUANTUANDUIHEQINGHUADAXUEYANCHUANGYEJIAOSHOUHEZUOZAIPNASQIKAN(IF:9.580)SHANGFABIAOTIWEICryo-EM structure of C9ORF72-SMCR8-WDR41 reveals the role as a GAP for Rab8a and Rab11aDEYANJIULUNWEN。GAILUNWENLVXIANBAODAOLERENYUANC9ORF72-SMCR8-WDR41(CSW)DANBAIFUHETIJINGXISANWEIKONGJIANJIEGOU,BINGQIESHOUCIJIESHILECSWFUHETIJIHUOXIAYOUXIAOGDANBAIDEFENZIJILI。

JIWEISUOXINGCESUOYINGHUAZHENG(Amyotrophic lateral sclerosis,ALS)HEENIEYEXINGCHIDAI(frontotemporal dementia,FTD)DOUSHUYUSHENJINGTUIXINGXINGJIBING,YANJIUFAXIANC9ORF72(chromosome 9 open reading frame 72)ZHONGLIUHEGANSUANZHONGFUXULIE(GGGGCC)DEDALIANGKUOZENGSHIALSHEFTDDEYICHUANXUEBINGYIN,DANSHIJUTIDEZHIBINGJIZHIHAIBUQINGXI。JINNIANLAIDEYANJIUBIAOMINGC9ORF72NENGYUSMCR8(Smith-Magenis syndrome chromosomal region candidate gene 8)HEWDR41(WD40 repeat-containing protein 41)YIQIXINGCHENGWENDINGDEFUHETI(CSWFUHETI),GAIFUHETIKEYIDIAOJIEZISHI。ZISHISHIXIBAONEIJIANGJIEJIAODADANBAIJUJITIDEWEIYITUJING,ERDANBAIZHIWENTAISHIDIAOSHIALSHEFTDDEGUANJIANBINGLITEZHENG。SUIZHEYANJIUDESHENRU,KEYANGONGZUOZHEZHENGSHICSWFUHETIKENENGZAIZISHIGUOCHENGZHONGFAHUIZHEDUOZHONGZUOYONG,BAOKUOJIEDAOULK1HERab GTPasesDEHUOXING,YINCIGAIFUHETIKENENGTONGGUODIAOKONGZISHIHEMOYUNSHULAIQINGCHUSHENJINGYUANZHONGDEDANBAIJUJITI,DANJUTIDEDIAOKONGJIZHIHAIBUQINGXI,BINGQIEGAIFUHETIDEJUTISHENGLIGONGNENGRENGRANBUMINGQUE。


极速11选5 ZAIGAILUNWENDEYANJIUZHONG,ZUOZHETONGGUOLENGDONGDIANJINGHERabHUOXINGFENXIDENGSHENGHUASHIYANTANJIULEQIGONGNENG,QUDEJIAOXINDEYANJIUJIEGUO:BAODAOLERENYUANCSWFUHETIJINYUANZIFENBIANLVDELENGDONGDIANJINGJIEGOU;ZHENGMINGLECSWFUHETISHIYIGEERJUTI:FUHETINEISANGEYAJIDEMOERBIWEI2:2:2,BUSHIZHIQIANWENXIANZHONGRENWEIDE1:1:1;CHANSHILECSWFUHETIZHONGLIANGGECSWYUANTIERJUHUADEJIZHI:ERJUHUASHIYOUC9ORF72 CDUANQUYUHESMCR8DEDENNJIEGOUYUGONGTONGJIEDAODE,ZHEIZHONGJIEHEFANGSHIYIQIANHAIWEIZAIDENNJIEGOUYUZHONGGUANCHADAOGUO;MINGQUELECSWYUANTIDEZUZHUANGJIZHI:WDR41TONGGUOCDUANαLUOXUANHESMCR8DEDENNJIEGOUYUJIEHE,WDR41HEC9ORF72ZHIJIANMEIYOUZHIJIEDEXIANGHUZUOYONG;GAILUNWENSHOUCIZHENGMINGLECSWFUHETIDUIRab8aHERab11aJUYOUGAPHUOXING,QIEJIANDINGCHUSMCR8DEArg147SHIFUZEQIGAPCUIHUAHUOXINGDE“arginine finger”。 ZHEIXIECHUANGXINXINGDEFAXIANDUIYUJINYIBUYANJIUCSWFUHETIDESHENGLIGONGNENGJIQIYICHANGDAOZHIXIANGGUANJIBINGFASHENGDEFENZIJIZHIJUYOUZHONGYAODEZHIDAOYIYI。

极速11选5 CSWFUHETILENGDONGDIANJINGJIEGOUJIQIDUIRabDEDIAOKONGMOXING。(A)CSWFUHETIDELENGDONGDIANJINGJIEGOU。(B)CSWYUANTIDEZUZHUANGJIZHI。(C)CSWFUHETIDUIRabDEDIAOKONGMOXING。

HUAXIYIYUANSHENGWUZHILIAOGUOJIAZHONGDIANSHIYANSHIBOSHIYANJIUSHENGTANGDANHESHUOSHIYANJIUSHENGSHENGJINGWEN、XULIANGTINGWEIBINGLIEDIYIZUOZHE,HUAXIYIYUANSHENGWUZHILIAOGUOJIAZHONGDIANSHIYANSHIDEQISHIQIANYANJIUYUANHEQINGHUADAXUESHENGMINGKEXUEXUEYUANYANCHUANGYEJIAOSHOUWEITONGXUNZUOZHE,SICHUANDAXUEHUAXIYIYUANWEIDIYIDANWEI。


YUANWENLIANJIE:

作者:沈国波 编辑:史杰蔚 周亮 来源:生物治疗国家重点实验室
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